Fat Smack - BURN BABY BURN!
Fat Smack, designed by PURUS LABS, follows the product development guidelines of PURUS regarding the use of ingredients that have demonstrated positive results, in relation to the product goal, in this case, fat loss. These ingredients should be research-proven using human test subjects and an oral form of ingestion and should be at the exact dosages that have been proven in the research. Fat Smack uses a specialized ingredient blend, with each individual compound selected for it's perceived result on fat loss. PURUS LABS does not use "window dressing" ingredients that do nothing more than look good in the ads. The logic that drives PURUS LAB is brevity and precision.
Caffeine is well researched, effective and commonly used. Caffeine's well known effects include: improved mood, cognition improvement, increased exercise performance, and several fat loss benefits (e.g., increased thermogenesis [Belza et al., 2009] such as increased free fatty acid release, increased catecholamine levels [Patwardhan et al., 1980],and suppressed appetite. While response to caffeine varies from individual to individual and is based on tolerance levels, typical research dosage amounts range from 3-6 mg∙kg-1 body weight.
2-amino-4-methylhexane seems to promote effects similar to the sympathetic nervous system, such as the endogenous chemicals dopamine, epinephrine and norepinephrine. This ingredient seems to mimic their effects as opposed to increasing the effects, such as: increased fatty acid mobilization from stored fat and providing a euphoric feeling. This particular ingredient is not yet supported by peer-reviewed, published research data. However, research is ongoing, and numerous initial reports suggest it's benefits for improved mood, increased focus, improved exercise performance, and extreme hunger control. The dose of this compound used in Fat Smack is based on studies using human test subjects with 2-amino-4-methylhexane used alone and with caffeine.
Cissus quadrangularis is used in Thai, traditional African and Ayurvedic medicine. Much like green tea , CQ provides several physiological benefits which include: strong antioxidant effects shown to combat oxidative stress, arthritis prevention benefits and anti-obesity functions. The chemical components of CQ ( flavonoids, phytosterols and keto-steroids) have been used in three human studies with each one reporting beneficial effects on fat loss and related aspects to fat loss. This research has shown that CQ alone, or combined with other compounds, caused statistically substantial reductions in overall body weight, body fat levels, waist size and cholesterol levels (Oben et al., 2006-2007-2008). The results so far for CQ are very impressive,to say the least.
Capsaicinoids are the active compounds found in such capsicum fruits as hot chili peppers. The most common forms of capsaicinoids in hot red peppers are capsaicin (8-methyl-N-vanillyl-6-nonenamide), dihydrocapsaicin, and nordihydrocapsaicin (Thomas et al., 1998). Capsaicinoid ingestion results in strong feelings of heat. In fact, the amount of heat generated is actually measured using Scoville Heat Units (SHU), with pure capsaicin achieving the highest measure of 15,000,000 SCU. This means that very little capsaicin in required to provide a beneficial effect, too much can result in gastrointestinal distress. In terms of fat loss effects, in numerous studies capsaicinoids have been shown to reduce food ingestion, increase thermogenesis, energy expenditure and lipolysis (for a review please see Bloomer et al., 2009b), and inhibit adipogenesis (Hsu and Yen, 2007). It's theorized that Capsaicinoids stimulates thermogenesis by activating the sarcoplasmic reticulum Ca+-ATP-ase (SERCA). Thermogenesis means the process of heat generation by the hydrolysis of ATP via SERCA. In the presence of capsaicinoids, SERCA becomes "uncoupled", this means that ATP hydrolysis happens without calcium transport, this leads to greater heat production (Mahmmoud, 2008). Relating to lipolysis, capsaicinoids are considered to be an agonist of the transient receptor potential vanilloid subfamily member 1 (TRPV1). TRPV1 ultimately leads to an enhanced activation of the sympathetic nervous system which in turn leads to the release of epinephrine and norepinephrine. From here, these anorectic catecholamine hormones interact with hormone sensitive lipase, this is an enzyme that's involved in lipolysis and fatty acid mobilization from fat storage sites in the body. Studies appear to show benefits between ingesting foods that contain capsaicinoid and lowered levels of obesity (Wahlqvist and Wattanapenpaiboon, 2001).
Vitamin & Mineral Matrix
The vitamin/mineral matrix is meant to increase the antioxidant potential of the other ingredients in FatSmack, such as EGCG and CQ, post-digestion catechin recovery (Vitamin C-see above EGCG) (Henning et al., 2004), and maximum thyroid function support (several studies can be found in support of the vitamin/mineral matrix regarding healthy thyroid-see PubMed, Linus Pauling Institute, and the NIH Office of Dietary Supplements). Several of the ingredients are known to support a healthy thyroid (vitamin A, selenium, iodine, iron, and zinc). A healthy thyroid is critical for metabolic rate regulation (energy expenditure). No wild claims are made as far as increasing thyroid activity beyond normal healthy function. Instead, Fat Smack is driven by a combination of research supported ingredients, each one thought to support healthy thyroid function and used by human test subjects.
Piperine, an extract of black pepper, seems to function in a manner much like capsaicinoids (binding the TRPV1 receptors) by increasing catecholamine secretion, resulting in thermogenesis. Piperine is often used in supplements as an aid in the absorption of certain nutrients such as curcumin, vitamins and amino acids from the gastrointestinal tract. (Johri, R.K. et al., 1992)( Kowado, T, et al., 1988)
Fat Smack contains a specialized blend of ingredients at research level dosages, based on human evidence relating to several aspects of fat loss. Regular exercise and sound dietary practices, such as frequent, nutrient dense meals (as well as sufficient water intake) should be the most important thing in regards to fat reduction. The use of a fat loss product like Fat Smack may provide additional results over this approach.