In the development of eNOXIDE, the MuscleMeds research team undertook a massive review and evaluation of the Nitric Oxide (NO) precursor and stimulating products on the market and numerous Nitric Oxide research studies to determine the best way for boosting NO levels. After extensive review, MuscleMeds scientists discovered that the NO precursor and NO stimulating products were at best minimally effective in elevating NO in the bloodstream, with individual effectiveness results varying. A plethora of research indicates the dose-response limitations of using orally administered arginine or other arginine based compounds, such as Arginine, Arginine Alpha-Ketoglutarate (AAKG), Citrulline and other NO precursors and stimulators. For example, when reviewing the research conducted using arginine, it was found that in order to achieve some elevation of NO, very large dosages of arginine were required, using intravenous administration. Even more problematic, the research reveals that the oral dosage methods used by all supplements (capsules, tablets, powder mixes, liquid drinks, etc.) were much less effective compared to intravenous (I.V.) administration.
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