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STIMULANT-FREE ADRENERGIC WEIGHT-LOSS STACK! NO CAFFEINE or ASPIRIN! Thermics is a stimulant-free diet aid that takes a new approach to adrenergic weight loss. Our patented* formula supports lipolysis (fat oxidation) without the use of caffeine, so you are not faced with the uncomfortable jitters and restlessness often associated with stimulant-based thermogenics. At its core are octopamine and yohimbine, a potent beta-3 receptor agonist and alpha-2 antagonist respectively, which trigger two pathways vital to fat loss but devoid of strong central nervous system activity. Bergenin and decaffeinated green tea extract (high in levels of epigallocatechin gallate) are added for their abilities to enhance adrenergic lipolysis without direct CNS stimulation, allowing us to create the first truly effective and comfortable replacement for E/C/A.
Octopamine is a potent naturally occurring selective beta-3 adrenergic receptor agonist, and has been shown in in-vitro animal studies to exhibit strong lipolytic activity in fat cells. It is also the first selective beta-3 agonist ever to be isolated and made available as a nutritional supplement, and given the understanding we have of beta-3 receptors and their ability to mediate human fat loss we believe it holds tremendous promise as a powerful, comfortable and safe fat-loss alternative to a non-selective beta agonist.
Beta-3 adrenergic receptors have been isolated in both human white and brown adipose tissues, and are now understood to play an important role in lipolysis and thermogenesis in our bodies. They are vastly more important here than previously thought by scientists, who had difficulty in the past discerning the contribution of each beta-receptor subtype (beta 1,2 and 3) without having agents selective for each to investigate. Early reports were actually not in favor of beta-3 receptors having much of a role in adult humans, or even being present in fat tissues at all. During the mid to late 1990's our view of this receptor finally began to change, however, with the publishing of a number of new studies. Using beta-receptor blocking agents (antagonists), investigators were able to demonstrate that beta-3 agonist activity likely accounted for at least 40% of the thermogenesis induced by this weight loss drug. Its strong action here seems not to be due only to beta-1 and beta-2 activation as we incorrectly believed earlier. Several other papers, as are referenced above, reported the isolation of beta-3 receptors in human fat tissue around the same time, and further demonstrated its role in triggering lipolysis and thermogenesis.
When a synthetic selective beta-3 agonist was finally developed and studied in human trials in 2001, the notion that this type of agent could actually be an effective weight loss option became an unquestionable fact. During these trails a group of 12 otherwise healthy overweight men noticed a clear increase in lipolysis, as well as total energy expenditure, with the use of a beta-3 agonist exclusively. We are sure the intended action of the drug was solely responsible for these effects because heart-rate and diastolic blood pressure did not increase in any of the subjects (signs that non-selective beta agonistic activity were occurring), nor did the concentrations of the endogenous adrenergic hormones epinephrine and norepinephrine. Leptin, a hormone often relevant to weight loss, also did not change during the study. We are left with proof that beta-3 agonists can be important triggers of lipolysis and thermogenesis in humans, and have opened a new door to weight loss without the uncomfortable jitters and central nervous system stimulation noted with non-selective beta agonists
Adrenergic lipolysis in human adipose tissue is regulated in a dual nature by adrenoceptors. Most notably, activation of the beta-1, beta-2 or beta-3 subtype increases the process of lipolysis; while activation of alpha-2 receptors diminishes it (fat cells appear to be the only type of cells in the human body that exhibit such dual regulation by adrenoceptors). Yohimbine, sold as a drug in some other countries, is an extremely potent naturally-occurring alpha-2 receptor antagonist (it blocks this receptor instead of activating it). Studies with this compound have consistently shown that as a result it is capable of increasing lipolysis in humans after oral dosing, via both alpha-2 receptor antagonism and increases in synaptic norephinephrine release. In effect it serves both beta stimulating and alpha blocking properties, an ideal combination if we want to stimulate fat loss. However, when single doses as high as 21.6mg, or daily cumulative doses as high as 43.2 mg, were taken in these studies the agent was well tolerated, and had no significant impact on blood pressure or heart rate as would be expected of a non-selective beta-agonist.
It is of note that yohimbine seems to work most effectively in the fasted state, and its lipolytic action may be blocked if it is taken with a meal. For the reason it may be a good idea to take Thermics on an empty stomach.
Decaffeinated Green tea extract has been added specifically for its high EGCG (epigallocatechin gallate) content, which is thought to be the most pharmacologically active tea catechin in green tea. Green tea has been around for centuries, and has been used in herbal medicine for about as long. Early on its beneficial properties were noticed, particularly in Asian cultures where is widely consumed and often thought of as a having numerous positive health benefits. In recent years scientists have been investigating the content and actions of Green Tea, and are coming to confirm with solid evidence many of its positive effects including those as an anti-oxidant, cholesterol lowering, antidepressant, capillary-strengthening and lipolysis-enhancing agent. Its inclusion in Thermics is a result of its documented ability to support thermogenesis and lipolysis in human studies.
Early suggestions were that its caffeine content was solely responsible for this effect; however this belief was dismissed in a study published in 1999 that demonstrated green tea to have an effect that could not be duplicated with an equivalent dose (50mg) of caffeine. In this investigation green tea increased 24 hour energy expenditure significantly, while the caffeine actually had no noticeable effect at all. It looks now like its high content of tea-catechins, particularly EGCG, which are the source of its positive activity here. Studies with purified EGCG seem to support this notion, showing this catechin to exert a direct effect on thermogenesis by increasing the respiration rate of brown fat cells. In-vitro tea catechins were also shown to inhibit the COMT enzyme, which is responsible for degrading the adrenergic hormone nor ephinephrine. Since norepinephrine has an important role in human thermogenesis and fat metabolism, this might account for at least some of its positive action here.
In keeping with our goal of a comfortable jitter-free thermogenic we have opted to use an extract high in catechins and EGCG but devoid of caffeine. Our Decaffeinated Green Tea Extract is standardized for 90% catechins and 60% EGCG content.
Bergenin is an isocoumarin found in a number of plant species including Bergenia crassifolia (siberian tea), Mallotus japonicus, Astilbe thunbergii (Ostrich Plume) and Ardisia japonica (Marlberry). It has a long history in Asian and Indian natural medicine, where it can be found in various herbal extract forms purported to exhibit anti-arrhythmia, astringent, tonic, anti-obesity and laxative properties. In recent years it has been looked at in western medicine as purified bergenin, with early studies reporting several potential benefits to this agent including anti-hepatotoxic (liver protecting), antiarrhythmic and ulcer fighting activities. Like EGCG, bergenin has also been shown to be capable of augmenting the lipolytic action of agents acting on the adrenergic system. Studies have confirmed that while the compound itself does not directly stimulate lipolysis or have measurable adrenergic activity; it markedly enhances lipolysis induced by an adrenergic hormone such as norepinephrine, and even opposes the lipogenic (fat building) actions of insulin. Its exact mode of action is unknown at this time, but it is believed to involve increased norepinephrine binding to fat cells.
With all 4 agents in place, Thermics represents the most effective and complete approach to adrenergic-mediated weight loss devised without the side effects of other strong stimulants!
One capsules supplies the following ingredients:
Octopaleantm - 150mg
Decaffeinated Green Tea Extract - 100mg
(Standardized for 90% catechins, 60% EGCG)
Bergenin - 100mg
Yohimbe Extract - 37.5mg
(standardized for 8% yohimbine)
Magnesium Stearate and Maltodextrin
Adults take 1-2 caps, 2-3 times per day. Do not exceed 12 weeks of continuous use.
Do not use if you are pregnant or nursing. Use only under the supervision of a doctor if you suffer from a medical condition such as high blood pressure, heart disease, or are taking any medication.
* No claims found on this web page or in print have been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. No claim or opinion about weight loss, bodybuilding or general health on this web page is intended to be, nor should be construed to be, medical advice. Please consult with a healthcare professional before starting any weight loss diet or exercise program.