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Nitric oxide (NO) is an important cellular messenger chemical that's essential in many biological processes. Its use as a sports supplement has increased greatly over the past few years, even though it's really a 'pre-workout' supplement. As such, NO-associated compounds are only a small percentage of the ingredients in many popular supplement formulations.
Even though NO supplements are the talk of the industry, very few people really understand exactly how they work. When the amino acid L-arginine is reaches the cells of the inner layer of arterial walls, the enzyme nitric oxide synthase (NOS) forms nitric oxide; thus, L-arginine is a precursor of NO.
When NO levels rise, blood vessels vasodilate (widen), which leads to increased blood volume (known in the bodybuilding world as 'the pump'). This is the effect bodybuilders are looking for, because it makes the most of the grueling exchange of oxygen, glucose, amino acids, creatine, and waste byproducts of muscular contraction such as lactic acid that are part of the response of the muscle during and immediately after an intense workout.
One idea that seems logical is to supplement with L-arginine to enhance the production of NO. However, NO chemistry is not that simple. L-arginine has many other roles in the body than just as a precursor of NO, and in vitro studies have shown that most of the time NOS is saturated with its L-arginine substrate. In simple language, L-arginine is abundant enough in the body that it doesn't limit the action of the NOS enzyme, and taking it orally for the purpose of increasing L-arginine levels doesn't appear to make any difference in the amount of NO produced.
However, some in vivo studies show a different result. Some of these studies suggest that under certain physiological conditions, increasing the amount of L-arginine in the body can enhance vasodilation and NO production. This may occur because of interference with compounds that usually inhibit NOS. The conflicting results between the two types of studies is called the 'arginine paradox.'
There isn't enough scientific data yet to confirm whether or not intense muscular contraction creates a physiological environment in which supplemental L-arginine can increase the activity of NOS and thus enhance the level of NO in the body. Despite this lack of scientific evidence, 'real-world' anecdotes from many gyms across the country suggest that NO supplements do, in fact, contribute to enhanced levels of NO.
However, even this evidence is unclear. The formulations of these popular NO products also contain many other beneficial pre-workout compounds that aren't related to the production of NO. As a result, it's impossible to tell how much these other compounds may contribute to vasodilation already taking place in the body because of the workout itself.
The physiological state that results from the beginning of an intense workout may, in fact, tip the 'arginine paradox' in the direction of L-arginine enhanced NOS activity and NO production. If that's the case, the sports supplement industry still has failed to create the best possible NO products, because current product formulations don't utilize L-arginine effectively to push the limits of NO production. The enzyme arginase easily breaks down L-arginine too soon for it to be useful; this has led other supplement companies to bypass arginase by substituting a precursor of L-arginine called L-arginine alpha-keto-glutarate (AAKG).
Unfortunately, this adds a step in the enhancement of NO production by introducing an intermediary compound into the process. This may mean that the entire process of supplying optimal levels of L-arginine to the body for NO production is utterly inefficient.
On the other hand, Hi-Tech Pharmaceuticals uses a 'straight up the middle' approach by shooting high levels of L-arginine into the bloodstream along with very potent arginase inhibitors. These inhibitors bond to arginase enzymes, which make these enzymes unable to prevent L-arginine from joining with NOS enzymes to create NO. This is an entirely new method of increasing NO production, which Hi-Tech Pharmaceuticals uses in its N.O. Overload Muscle & Strength supplement.
Nitric oxide (NO) sports nutrition is rapidly becoming one of the largest sports nutrition product categories. In spite of dozens of 'advancements' in NO supplementation, however, traditional NO sports nutrition has retained one basic flaw. This flaw is easy to see when you look at the formulations of NO products throughout the sports nutrition industry. The formulations of these products show a lack of understanding of the most efficient way to provide L-arginine for the production of NO, which is to incapacitate the enzyme arginase.
This is important because arginase is the enzyme that breaks down arginine. Arginine, in turn, is a problem for NO supplements because arginine is the source of NO production. Hi-Tech Pharmaceuticals is the only supplement company that has figured out how to tackle the arginase problem directly: they take arginase out of the NO equation completely.
Hi-Tech uses 2(S)-amino-6-boronhexanoic acid (ABH) and S-(2-boronethyl)-L-cysteine HCl (BEC), the arginase inhibitors in N.O. Overload, to support the high dosage of L-arginine and to render the arginase useless.
This leaves a large amount of pure L-arginine in the muscle pool. This creates an abundance of NO, leading to the greatest possible muscular vasodilation.
However, there's more to this story.
N.O. Overload is just what it says it is...an overload of NO. It's jacked up with more than other 30 compounds that include three arginase inhibitors, nine muscle cell volumizing and work performance compounds, five NO drivers, six energy complex components, and four amino acid recovery agents.
N.O. Overload is designed to act before the workout to accelerate muscle growth by creating a "feeding pool" of compounds that improve the intensity of training and work performance. These compounds also set up your muscles for more rapid recovery and enhanced muscular growth.
N.O. Overload empowers your muscles throughout your entire training session. It provides the very best that sports supplement science has to offer in utilizing the potential benefits of increased NO production, and floods your system with the top pre-workout compounds known to nutraceutical sports science. This creates the most efficient muscle-building environment possible.
Serving Size: 1 Scoop
Serving Per Container: 40
Amount Per Serving
Calories - 25
Total Carbohydrates - 6 2%
Sugars - 0
Vitamin B-6 (Pyridoxine HCl) - 30mg
Vitamin B-12 Matrix - 120mcg
Sodium - 220mg
Phosphorus - 500mg
NO Overload - 25,000mg
Proprietary Precision Growth Blend
Nitric Oxide Blend with Micro-Rx and Extend Rx Technology
L-Arginine AKG, L-Arginine Ethyl Ester Dihydrochloride, L-Arginine HCl
L-Arginine Malate, Glycine-L-Arginine-Alpha-Ketoisocaproic Acid
Hi-Tech Arginase Inhibitors
2(S)-Amino-6-Boronohexanoic Acid (ABH), S-(2-Boronethyl)-L-Cysteine
HCL (BEC), L-Norvaline
Hi-Tech Muscle Cell Volumizing and Performance Technology
Disodium Creatine Phosphate Tetrahydrate, Creatinol-O-Phosphate, Creatine
Ethyl Ester HCl, Creatine Monohydrate, Di-Creatine Malate, Inosine Ethyl
Ester HCl, Adenosine Triphosphate Sodium, Taurine Ethyl Ester
HCl, GuanidinopPropionic Acid
Thermo-Rx and Hi-Tech Energy Complex
Acacia Rigidula 98% Extract (as Thermo-Rx)(Leaves), Yerba Mate Extract,
Theobromine Anhydrous, Quebracho Blanco Extract (Bark), L-Tyrosine Ethyl
Ester HCl, Beta-Alanine Ethyl Ester HCl
Hi-Tech Recovery Rx
L-Leucine Ethyl Ester HCl, L-Isoleucine Ethyl Ester HCl, L-Valine Ethyl
Ester HCl, L-Glutamine Ethyl Ester HCl
Training Days: Once your tolerance has been established, mix 1-3 scoops with 6-18 oz. of cold water and consume 30-45 minutes before training. Use approximately 6 oz of water per 1 scoop of powder.
Non-Training Days: Mix 1 scoop with 6 oz of water and consume on an empty stomach. Vary the amount of water to achieve your desired flavor and sweetness level.
* No claims found on this web page or in print have been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. No claim or opinion about weight loss, bodybuilding or general health on this web page is intended to be, nor should be construed to be, medical advice. Please consult with a healthcare professional before starting any weight loss diet or exercise program.