Plasmagen Nitrate delivers:

• Increases in anaerobic and aerobic performance, strength, and muscular endurance
• Improvements in muscle contraction and muscle growth
• Boost in oxygen utilization
• Delayed onset of muscle fatigue
• Rapid recovery
• Elevated protein synthesis leading to dense, lean muscle mass
• Enhanced nitric-oxide synthesis, producing vascularity and pump
• Improved glycogen synthesis
• Increases in fatty-acid metabolization, leading to noticeable fat-loss
• Elevated mitochondrial function, fat metabolism, and myocardial health
• Potent antioxidant support and immune enhancement

Beta-Alanine

Beta-Alanine (3-aminopropanoic acid) and L-Histidine are the building blocks of the multifunctional dipeptide, L-Carnosine (L-beta-alanyl-L-histidine). The only naturally occurring beta amino acid (the amino group is attached to the beta (�) position relative to the carboxylate group), beta-alanine is also a constituent of calcium pantothenate, or vitamin B5. When we supplement with carnosine, or consume foods containing carnosine, a highly active enzyme referred to as carnosinase degrades carnosine into its precursors, beta-alanine and l-histidine. These amino acids are subsequently absorbed into skeletal muscle cells where they are resynthesized (or re-combined) to carnosine by an enzyme called carnosine synthase. High intensity exercise is known to produce elevations in lactic acid concentrations as well as produce high H+ (hydrogen ions) concentrations. These increased levels lead to rapid onset of fatigue and decreased performance. Carnosine turns out to be an important metabolic buffer in skeletal muscle cells by promoting the neutralization of lactic acid, thereby enhancing performance and muscle contraction. Research suggests that skeletal muscle concentration of carnosine promotes performance and muscle contraction during periods of high intensity exercise.

The following is just as significant: Carnosine is found in both Type I and Type II muscle fibers, although it is preferentially found in fast-twitch (Type II) muscle fibers in humans. Type II muscle fibers are those with a significant potential for growth. Type I, or slow-twitch muscle fibers, on the other hand, have a limited capacity for growth. As it turns out, most of us have more Type I than Type II. Yet, by preferentially increasing carnosine concentrations in Type II muscle fibers and stimulating their growth, we can maximize the growth capacity of these fast-twitch fibers.

Furthermore, L-Carnosine is considered one of the most potent antioxidants available, as it possesses the unique ability to quench the destructive effects of a broad variety of free radicals. L-carnosine also appears to protect cellular DNA integrity from oxidative damage, leading to cell-protective effects associated with markers of an effective anti-aging agent.

Although carnosine is made up of both beta alanine and l-histidine, research has demonstrated that beta alanine is the limiting factor in carnosine synthesis, as l-histidine is readily available in required quantities in diet. This means that beta alanine supplementation is a convenient and effective way to boost intra-cellular carnosine concentrations. Consequently, beta-alanine supplementation delays the onset of muscular fatigue, boosts energy levels and the efficiency of aerobic exercise, boost endurance levels, and supports the synthesis of nitric oxide.

So what does all this mean? Simple! With beta-alanine, you can effectively boost cellular carnosine concentrations. This will help neutralize lactic acid and hydrogen ion levels, leading to delayed fatigue, increased performance and endurance, strength increases, intense muscle contractions, and radical improvements in the development of fast-twitch muscle fibers, providing significant growth in dense, lean mass. Beyond this, carno sine via beta-alanine provides superior antioxidant protection, improved mitochondrial function, and enhanced immune support. Simply one of the most potent all-round supplements around! Plasmagen provides you with a generous per-dose amount of this compound, matching the quantities employed in successful clinicals.

L-Citruline-DL-Malate

Formed in the mitochondria via a combination of carbon-dioxide, ammonia, and ornithine, Citrulline is a non-essential amino acid intricately involved in nitrogen balance and regulation of diverse metabolic processes. Outside of the mitochondria, citrulline can be converted to arginine. Citrulline malate is a salt form of citrulline, and is formed by bonding citrulline to malic acid. Considering that malate is a Krebs Cycle intermediate (in addition to citrate, fumarate, succinate, and alpha ketoglutarate), the citrulline malate form unites several cool benefits, including regulation of aerobic cellular respiration and the generation of energy in the mitochondria. Citrulline is vital for the detoxification and elimination of ammonia from liver and muscle cells. More specifically, ammonia is produced in muscle cells as a by-product of the breakdown of proteins during intense physical exertion. This ammonia can either accumulate in the muscle cells or in the liver, leading to toxicity and compromising the protection of cells from dangerous ions. Via a sequence of reactions, ammonia combines with ornithine and carbon dioxide in the mitochondria to form citrulline. Citrulline is then converted to arginine. In this process, therefore, ammonia detoxification is elegantly completed. In muscle and liver cells nitrogen and carbon dioxide produce urea that is finally excreted via the kidney as urine.

By promoting adequate tissue concentration of adenosine triphosphate (ATP) and creatine phosphate (a form of ATP), and by recycling lactate and reducing hydrogen ions, citrulline malate radically boosts energy, aerobic and anerobic performance, and recovery. This is significant because intense muscular exertion leads to the production of lactic acid. Lactic acid, in turn, creates the so-called "burn" during intense muscular stress, reducing muscular output and performance and forcing the athlete to end his routine and recover. So, the removal of lactic acid from the blood promotes rapid recovery.

Furthermore, citrulline malate plays an important role in the regulation of nitric oxide. In particular, several benefits from citrulline malate supplementation are intimately connected to its role in endogenous regulation of plasma levels of arginine. Specifically, citrulline (malate) has been shown to be more effective than arginine in boosting endogenous plasma arginine levels (Yearick et al, 1967).

Altogether, citrulline malate supplementation dramatically boosts endurance, promotes rapid recovery from intense muscular exertion, and boosts the synthesis of nitric oxide. Plasmagen Nitrate delivers an effective dose of citrulline malate to drive you workout intensity and recovery!

Arginine Ethyl Ester DI-HCL

A conditionally essential amino acid,=2 0arginine has several metabolic functions, one of the central ones being its role in nitric-oxide synthesis. Others include its beneficial effect on creatine syntheses. L-Arginine is the substrate for two enzymes, arginase and nitric oxide synthase. These enzymes compete against each other for the arginine metabolic pathway. The enzyme arginase converts arginine to ornithine and urea. Nitric oxide synthase converts arginine to nitric oxide, the potent vasodilator. A higher expression of the arginase enzyme leads to higher ornithine production, but less nitric oxide production. Now, adenosine, adenine, inosine, uric acid, citrulline malate, magnesium tanshinoate B, and beta alanine are some of the known competitive arginase inhibitors. Such arginase inhibition produces an elevated expression of the nitric-oxide synthase enzyme. This means even more nitric oxide can be produced from arginine, leading to stronger vasodilation (and pump). An optimal approach to boosting nitric-oxide synthesis would, therefore, require a combination of stimulation of nitric-oxide synthase and arginase inhibition. Several compounds in Plasmagen Nitrate cover both paths to provide superior vasodilation and vascularity!

As it turns out, standard arginine (L-Arginine) has several limitations. First, l-arginine is poorly absorbed and rapidly metabolised in the intestines, severely compromising its biological action.

The limitations of pure arginine make more advanced forms an imperative. These advanced arginine forms involve the bonding of arginine to another compound . Arginine Ethyl Ester HCL (AEE) is a superior arginine form created by the attachment of an ethyl ester to the arginine molecule. Esters are formed by the reaction of alcohols and carboxylic acid. Esterification overcomes the typical arginine limitations by making arginine less polar, hence easier to absorb in the digestive tract. Esterification also protects arginine from rapid degradation. Altogether, in its ethyl-ester form, arginine achieves superior stability, absorbs better, demonstrates bioavailability, and is able to produce improvements in arginine's ergogenic effects. Consequently, relatively small doses of AEE out-perform supra-physiological doses of standard arginine. Less is more! In particular, AEE potentiates nitric-oxide synthesis, leading to enhanced vasodilation and vascularity, flooding skeletal muscle cells with nutrient and oxygen-rich blood to create an environment conducive for anabolism. In this connection, arginine also supports muscle tissue repair (and growth), and consequently, faster recovery from exercise-induced stress.

Glycine Propionyl-L-Carnitine (GPLC)

Discovered in 1905, carnitine is a water-soluble compound with structural similarity to vitamins. Carnitine can, not only be synthesized in small amounts from the amino acid, L-Lysine, but can also be obtained from meat, fish, and poultry, and plays a crucial role in fat metabolism. More specifically, carnitine serves as the transport system for shuttling long-chain fatty acids into the body's fat-burning furnace, the mitochondria, where these fatty acids, the primary energy sources for skeletal muscle and heart cells, are metabolised (burnt) for cellular energy. Recall that short- and medium-chain fatty acids do not require a shuttling medium into the mitochondria, as they can penetrate the mitochondria without the help of a carrier. Carnitine is also involved in the elimination of toxic compounds from the mitochondria, further helping to reach and maintain optimal mitochondrial activity. Even though carnitine is available from food sources, an individual could also experience carnitine deficiency that expresses itself in the form of weakness, muscle pain, and propensity to fatigue.

Carnitine supplementation triggers higher fatty-acid oxidation in heart mitochondria, and also boosts adenosine tri-phosphate (ATP) and phosphocreatine (an ATP storage form) levels in heart tissue. By helping to boost myocardial (heart) metabolism and support mitochondrial function and ATP levels, carnitine may help support immune response and slowing the aging process.

While pure L-Carnitine can power mitochondrial function and cellular ATP, certain more advanced forms of l-carnitine are known to be significantly more effective and versatile in many directions than base carnitine. One of these forms is a potent, novel, and uniquely effective compound known as Glycine Propionyl-L-Carnitine (GPLC). GPLC is a propionyl ester of carnitine (PLC) with an additional glycine fraction that has an enormous affinity for heart, muscle, and endothelial tissue, leading to dramatic elevations in ATP/creatine-phosphate ATP synthesis and mitochondrial function (by dramatically improving the shuttling of fatty acids into the mitochondria to produce cellular energy in muscle cells, such as the heart), unmistakable improvements in endurance, delaying of the on-set of fatigue, as well as optimizing glycogen synthesis for further enhancement in energy and endurance. Furthermore, and this is a key part of this blend, GPLC acts like Idebenone (the potent analog of CoQ10) by directly contributing to the compensation for reduced availability of oxygen during exercise. Apart from promoting strength and endurance, GPLC also, like citrulline malate, reduces the build-up of lactic acid and supports the expulsion of toxic waste substances; and like beta-alanine and arginine ethyl ester, promotes superior arterial vasodilation and helps to maintain the structural integrity of endothelial cells.

As you can see, GPLC introduces substantial leverage into Plasmagen Nitrate by synergistically exponentiating the unique biological activities of the other agents in the matrix. With GPLC in this formula, 1+1 = 5! You will know when it hits you!

L-2-Aminopentanoic Acid

Also known as L-Norvaline (or L-Nor-Valine), L-2-Aminopentanoic Acid is a modified form of the branched chain amino acid, L-Valine, with unique biological effects. Unlike L-Valine, however, L-Norvaline is not involved in protein synthesis. Instead, L-Norvaline acts as a potent enzyme inhibitor. In particular, L-Norvaline directly inhibits arginase, the enzyme that acts to limit the production of nitric oxide. By inhibiting arginase, L-Norvaline dramatically increases nitric oxide synthesis, vasodilation, vascularity, muscle hardness and density. Furthermore, L-Norvaline stabilizes arginine, ensuring that it stays active longer. Combining the arginase-inhibition action of L-Norvaline with the nitric-oxide-synthase promoting actions of beta-alanine, magnesium tanshinoate B, and citrulline malate would shatter your natural nitric-oxide production limits and ensure your workouts will never be the same again!

Magnesium Tanshinoate B

Plasmagen Nitrate includes Magnesium Tanshinoate B (MTB) to create a20perfect blend of workout potentiators and recovery agents. MTB is an active hydrophilic compound purified from the dried root and rhizome of danshen (Salvia miltiorrhiza), the Chinese herb. Now you begin to see why we got interested in this unique compound! In particular, MTB boosts nitric oxide production in endothelial cells, leading to elevations in vasodilation and vascular tone. Besides, MTB's unique actions extend to supporting cardiovascular function already within normal range and boosting of cellular energy. Clearly, MTB is an important part of Plasmagen Nitrate, acting in synergy with the other agents in the blend to deliver workout intensity, vascular tone, muscle growth, rapid recovery, and optimised immune function.

Once you try Plasmagen Nitrate, you will never again settle for less! Challenge us!



Supplement Facts
 
Serving Size: 10 Capsules
Servings Per Container: 20

Amount Per Serving

Plasmafuze Proprietary Matrix - 7150mg
Beta Alanine, L-Citruline DL-Malate, Arginine Ethyl Ester DL-HCL, L-2-Aminopentanoic Acid, GPLC (Glycine Propionyl L-Carnitine), Magnesium Tanshinoate B

Daily Value not established*

Other Ingredients
Gelatin, Titanium Dioxide, FD&C Red #40, FD&C Blue #1.



Directions

For APS Plasmagen Nitrate: Suggested Use: On workout Days, Take 10 Capsules. Take 4 of those capsules approximately 6 hours before workout and the remaining 6 capsules 40 minutes before workout. On Non-workout days take 4 capsules (to maintain adequate carnosine and GPLC levels).



Warnings

Keep out of reach of children. This product is not intended for anyone under the age of 18, pregnant or nursing. Consult your physician before using this or any other dietary supplement. Do not take this product if you have any medical condition.



* No claims found on this web page or in print have been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. No claim or opinion about weight loss, bodybuilding or general health on this web page is intended to be, nor should be construed to be, medical advice. Please consult with a healthcare professional before starting any weight loss diet or exercise program.